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Background concern that hormone replacement therapy (hrt) may cause breast cancer has existed since the time it was introduced, and based on evidence in three studies, the collaborative reanalysis (cr), the womens health initiative (whi) and the million women study (mws), it is claimed that causality is now established. The whi demonstrated that the use of estrogen plus progestin hormone therapy after menopause increased the risk for heart disease, stroke, blood clots, breast cancer, and dementia. Although hormone therapy with estrogen alone had some benefits for younger women who had a prior hysterectomy, estrogen increased the risk for stroke and blood clots in these and other women in the study. For women in the whi cad who were not taking personal calcium or vitamin d supplements at randomization, cad decreased the risk of total, breast, and colorectal cancers and did not change the risk of fractures or total mortality. In a re-analysis of the recently released womens health initiative study, researchers showed a trend toward an increased absolute risk for breast cancer in women aged 50 to 59 years who take. Breast cancer and hormone replacement therapy collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer. This collaboration began in 1992, and has published on breast cancer risk associated with use of hormonal therapies and childbearing practices. 14 potentially eligible epidemiological studies have been sought at regular intervals by computer-aided literature searches, by written communication and discussions with colleagues, and by discussions at. In the whi randomized, placebo-controlled clinical trial evaluating estrogen alone in postmenopausal women with prior hysterectomy, intervention was ended after 7. 1 years (mean) because of an increased stroke risk and an absence of overall clinical benefit (figure 1) anderson et al. The breast cancer findings related to estrogen alone use differed.   the whi, however, found that estrogen-only therapy may not increase breast cancer risk and may actually decrease it, although that has not been confirmed in other research. Total cancer mortality did not differ significantly between intervention and placebo groups in either trial despite the increased incidence of breast cancer with cee plus mpa 34 and concerns about an increased risk of hormone-sensitive cancers with both regimens.

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